This is version 2.3.0 of MODICOS for Windows. 

This version allows to compute euclidean distances and centroid size (CS) from a set of coordinates x,y and use CS to estimate heritabilities and Qst. It also computes relative warps and uniform components of shape variation from a set of coordinates x,y and use any relative warp or uniform component to estimate heritabilities and Qst's.

The data type are values of individuals (points or phenotypes) belonging to families and populations. Thus, any individual is identified by a code that looks like 123.22.3. This is individual 3 from family 22 from population 123.

There are two different kinds of INPUT FILES:

1) COORDINATES
The header of the file must be [MODICOS - POINTS] (see example file 1). Under the header, what follows is the individual code and below each individual code a set of points, eg:

[MODICOS - POINTS]
17.22.2 (this is an individual code)
1.2,2.2 (this are x,y coordinates)
1,3
.
.
123.22.3 (this is an individual code)


The coordinate points can be separated by comma, space or tabulation.

NOTES
The decimal separator for coordinates should be a point (not comma).
When the relative warp analysis (RWA) is performed, two matrices are written in addition to the output file, the files RC.dat and R.dat. The first is the reference configuration matrix. The second is the relative warp loading matrix (see eq. 13 in Rohlf 1993, see bibliography in the online help of MODICOS), in this matrix the columns are the relative warps, the first p rows correspond to x-coordinates and the remaining p correspond to y-coordinates.

2) PHENOTYPES
The header of the file must be [MODICOS - PHENOTYPES] (see example file 2). Under the header, what follows is the individual code and below each individual code a phenotypic value, eg:

[MODICOS - PHENOTYPES]
123.22.2 (this is an individual code)
3.32 (this is a phenotypic value)
123.22.3 (this is an individual code)

If the input file is a coordinates file, i.e. has the header [MODICOS - POINTS], the results of computations are kept in memory so that one can inmediatly perform the genetic analysis (computations of heritabilities and Qst).


SYSTEM REQUIREMENTS
Please ensure your processor and equipment meets the following or MODICOS will not run properly: 

- An IBM compatible personal computer with a Pentium-Class Microprocessor. 

- MODICOS requires Windows 95(OSR2) with 32 MB RAM, Windows 98/ 98SE / ME with 64 MB RAM, Windows NT 4.0 with Service Pack 4 or better installed, Windows 2000 or Windows XP with 128 MB RAM. 

All statements are made without any warranty. 

Windows Service Packs can be located and downloaded from http://windowsupdate.microsoft.com

INSTALL
To install the program, unzip the Modicos.zip file and execute setup.exe.


COPYRIGHT
Copyright (C) 2004 by A. Carvajal-Rodriguez and M. Gandarela. MODICOS is free software; you can redistribute it under the terms of the GNU General Public License as published by the Free Software Foundation; either version 2 of the License, or (at your option) any later version. This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details. 


For help with this program contact

A. Carvajal-Rodríguez, Department of Bioquímica, Genética e Inmunología, University of Vigo (Spain).  
e-mail: acraaj@uvigo.es